Optimization of polyethylene terephthalate biodegradation using a self-assembled multi-enzyme cascade strategy

This is my first academic publication. After participating in the International Genetically Engineered Machine (iGEM) Competition 2023, I had the privilege of joining a protein engineering laboratory, where I became involved in the rational design of PETase under the guidance of Professor Juan Feng and Professor Lixia Tang. I developed a high-throughput pipeline for virtual mutagenesis and molecular docking, combined with molecular dynamics simulations, which effectively enhanced the enzymatic activity of PETase. I must say, I’ve also developed a strong passion for synthetic biology.

Recommended citation: Aer L, Jiang Q, Zhong L, Si Q, Liu X, Pan Y, Feng J, Zeng H, Tang L. Optimization of polyethylene terephthalate biodegradation using a self-assembled multi-enzyme cascade strategy. J Hazard Mater. 2024 Sep 5;476:134887.
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